Version 4.0 of the .NET Framework included a new CLR which is almost entirely backwards compatible with the 2.0 version of the CLR. However, by default, mixed-mode assemblies targeting .NET 3.5sp1 and earlier will fail to load in a .NET 4 application. Fixing this requires setting useLegacyV2RuntimeActivationPolicy in your app.Config for the application. While there are many good reasons for this decision, there are times when this is extremely frustrating, especially when writing a library. As such, there are (rare) times when it would be beneficial to set this in code, at runtime, as well as verify that it’s running correctly prior to receiving a FileLoadException.